Molekulare Bioenergetik

Prof. Dr. Ulrich Brandt

Publikationen 2006

Originalpublikationen und Reviews

  1. Carrozzo, R., Wittig, I., Santorelli, F.M., Bertini, E., Hofmann, S., Brandt, U.,Schägger, H. (2006) Subcomplexes of human ATP synthase mark mitochondrial biosynthesis disorders. Ann. Neurol.  59:265-275.

  2. Derbré,S., Duval,R., Roué,G., Garofano,A., Poupon,E., Brandt,U., Susin, S.A and Hocquemiller, R. (2006) Semisynthesis and screening of a small library of pro-apoptotic squamocin analogues: selection and study of a benzoquinone hybrid with an improved biological profile. ChemMedChem, 1:118-129.
  3. Mileni, M., Macmillan, F., Tziatzios,C., Zwicker, K., Haas,A.H., Mäntele, W., Simon, J., Lancaster, C.R. (2006) Heterologous production in Wolinella succinogenes and characterisation of the quinol:fumarate reductase enzymes from Helicobacter pylori and Campylobacter jejuni. Biochem. J. 395:191-201.
  4. Brandt, U. (2006) Energy converting NADH:quinone oxidoreductase (Complex I). Ann. Rev. Biochem. 75, 69-92..
  5. Duval, R. A.,  Lewin, G,. Peris, E., Chahboune, N.,  Garofano, A., Dröse, S., Cortes,  D., Brandt, U.  and Hocquemiller, R. (2006) Heterocyclic analogues of squamocin as inhibitors of mitochondrial complex I. On the role of the terminal lactone of annonaceous acetogenins. Biochemistry, 45:2721-2728.
  6. Maly, T., Grgic, L,. Zwicker, K., Zickermann, V., Brandt, U.  and Prisner T. (2006) Cluster N1 of complex I from Yarrowia lipolytica studied by pulsed EPR spectroscopy. J. Biol. Inorg. Chem. 11:343-350
  7. Radermacher, M., Ruiz, T., Clason, T., Benjamin, S., Brandt, U., Zickermann, V. (2006) The Three-dimensional Structure of Complex I from Yarrowia lipolytica: A highly dynamic Enzyme. J. Struct. Biol. 154:269-279.
  8. Marshall, D., Fisher, N., Grigic, L., Zickermann,V., Brandt,U., Shannon,R.J., Hirst,J., Lawrence,R., Rich,P.R. (2006) ATR-FTIR redox difference spectroscopy of Yarrowia lipolytica and bovine complex I. Biochemistry, 45:5458-5467.
  9. Wittig, I., Carozzo,R., Santorelli, F.M. and Schägger, H. (2006) Supercomplexes and subcomplexes of mitochondrial oxidative phosphorylation. Biochim. Biophys. Acta. 1757:1066-1072.
  10. Schägger, H., (2006) Tricine SDS PAGE. Nature Protocols, 1:16-22.
  11. Wittig,I., Braun,H.-P. and Schägger, H., (2006) Blue native PAGE. Nature Protocols, 1:416-428.
  12.  Duval, R., A.Poupon, E., Romero, V.,  Peris, E.,  Lewin, G., Cortes, D., Brandt U., and Hocquemiller R. (2006) Analogues of cytotoxic squamocin using reliable reactions: new insights into the reactivity and role of the a,b-unsaturated lactone of the annonaceous acetogenins. Tetrahedron 62:6248-6257.
  13. Dröse, S., Brandt, U., Hanley, P. (2006) K+-independent actions of diazoxide question the role of inner membrane KATP channels in mitochondrial cytoprotective signaling.  J. Biol. Chem. 281:23733-23739
  14. Schwab, M. A.,Sauer, S. W., Okun, J. G., Nijtmans, L. G., Rodenburg, R. J., Van den Heuvel, L. P., Dröse, S., Brandt, U., G. F. Hoffmann, G. F., Ter Laak, H., Kolker, S. and Smeitink, J. A. (2006) Secondary mitochondrial dysfunction in propionic aciduria, a pathogenic role for endogenous mitochondrial toxins. Biochem J. 398:107-112.
  15. Zwicker, K., Galkin, A.,  Dröse, S.,. Grgic, L, Kerscher, S. and Brandt.U.  (2006) The redox-Bohr group associated with iron-sulfur cluster N2 of complex I. J.Biol.Chem. 281:23013-23017.
  16. Busch, K. B., Bereiter-Hahn, J., Wittig, I., Schägger, H., and Jendrach. M. (2006) Mitochondrial dynamics generate equal distribution but patchwork localisation of respiratory complex I. Mol. Membrane Biol. 23:509-520.
  17. Burre, J., Beckhaus, T., Schägger, H., Corvey, C., Karas, M., Zimmermann, H., and Volknandt, W. (2006) Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques. Proteomics 6:6250-6262.
  18. Abdrakhmanova, A., Zwicker, K., Kerscher, S., Zickermann, V. and Brandt, U. (2006) Tight binding of NADPH to the 39-kDa subunit of complex I is not required for catalytic activity but stabilizes the multiprotein complex. Biochim. Biophys. Acta 1757:1676-1682.
  19. Garofano, A., Eschemann, A., Brandt, U., Kerscher, S. (2006) Substrate Inducible Versions of Internal Alternative NADH:Ubiquinone Oxidoreductase from Yarrowia lipolytica. Yeast 23:1129-1136.
  20. Poncet D., Pauleau A.L., Szabadkai G., Vozza A., Scholz S.R., Le Bras M., Briere J.J., Jalil A., Le Moigne R., Brenner C., Hahn G., Wittig I., Schägger H., Lemaire C., Bianchi K., Souquere S., Pierron G., Rustin P., Goldmacher V.S., Rizzuto R., Palmieri F., Kroemer G.. (2006) Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA. J. Cell. Biol. 174:985-996
  21. Bachmann, J.,  Bauer, B., Zwicker,K., Ludwig, B. and Anderka, O. (2006) The Rieske protein from Paracoccus denitrificans is inserted into the cytoplasmic membrane by the twin-arginine translocase. FEBS J., 273:4817-4830
  22. Galkin, A., Dröse, S. and Brandt, U. (2006) The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes. Biochim. Biophys. Acta 1757:1575-1581

Lehr- und Handbuchbeiträge, Monografien

  1. Löffler, G. und Brandt U. (2006) Kap. 14: Der Citratzyklus. In: Biochemie und Pathobiochemie (Löffler, G., Petrides, P.E. und Heinrich P.C. Hrsg.), 8. Auflage , Springer, Berlin-Heidelberg 100, pp 477-488.
  2. Brandt U. (2006) Kap. 15: Redoxreaktionen, Sauerstoff und oxidative Phosphorylierung. In: Biochemie und Pathobiochemie (Löffler, G., Petrides, P.E. und Heinrich P.C. Hrsg.), 8. Auflage , Springer, Berlin-Heidelberg, pp 489-514

Supplements / Abstracts

  1. Brandt,U. (2006). Structural and functional insights into mitochondrial complex I. Biochim. Biophys. Acta 1757(5-6) S70.

  2. Abdrakhmanova,A., Galkin,A., Schaegger,H., Kerscher,S., and Brandt,U. (2006). A proteomic study of complex I from the aerobic yeast Yarrowia lipolytica. Biochim. Biophys. Acta 1757(5-6) S135.

  3. Dobrynin,K., Abdrakhmanova,A., Zwicker,K., Kerscher,S., and Brandt,U. (2006). Investigation of two accessory subunits of complex I from Yarrowia lipolytica. Biochim. Biophys. Acta 1757(5-6) S153.

  4. Galkin,A. and Brandt,U. (2006). Interaction of diphenyleneiodonium with complex I in bovine submitochondrial particles. Biochim. Biophys. Acta 1757(5-6) S166.

  5. Marshall,D.C.A., Fisher,N., Grigic,L., Zickermann,V., Brandt,U., Shannon,R.J., Hirst,J., Lawrence,R., and Rich,P.R. (2006). ATR-FTIR redox difference spectroscopy of Yarrowia lipolytica and bovine complex I. Biochim. Biophys. Acta 1757(5-6) S208.

  6. Tocilescu,M.A., Zwicker,K., Brandt,U., and Kerscher,S. (2006). Exploring the environment of iron-sulfur clusters in complex I from Yarrowia lipolytica. Biochim. Biophys. Acta 1757(5-6) S241.

  7. Zickermann,V., Radermacher,M., Ruiz,T., Clason,T., Benjamin,S., Wrzesniewska,B., and Brandt,U. (2006). Functional implications from novel structural features in complex I from Yarrowia lipolytica. Biochim. Biophys. Acta 1757(5-6) S259.