Molekulare Bioenergetik

Prof. Dr. Ulrich Brandt

Publikationen 2005

Originalpublikationen und Reviews
  1. Hanley, P.J., Dröse, S., Brandt, U., Lareau, R.A.,  Banerjee, A.L., Srivastava, D. K., Banaszak, L.J., Barycki,  J.J.,  Van Veldhoven, P.P. and Daut,J. 5-hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for b-oxidation of fatty acids.  J Physiol  (2005) 562:307-318.

  2. Eschemann, A., Galkin, A., Oettmeier, W., Brandt, U. and Kerscher, S. HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH-dehydrogenase - evidence for a ping-pong mechanism. Journal of Biological Chemistry (2005) 280:3138-3142.

  3. Waletko, A., Zwicker, K.,  Abdrakhmanova,A., Zickermann,V., Brandt,U. and Kerscher,S. Histidine 129 in the 75 kDa subunit of mitochondrial complex I from Yarrowia lipolytica is not a ligand for Fe4S4 cluster N5, but is required for catalytic activity.  Journal of Biological Chemistry (2005) 280:5622-5625.

  4. David, D.C., Hauptmann,S., Scherping,I., Schuessel,K. Keil,U., Rizzu,P., Ravid,R., Dröse,S., Brandt,U., Müller,W.E., Eckert,A. and Götz, J.. Proteomic and functional analysis reveal a mitochondrial dysfunction in P301L tau transgenic mice. Journal of Biological Chemistry (2005) 280:23802-23814.

  5. Brandt, U.,  Abdrakhmanova,A., Zickermann,V., Galkin, A., Dröse, S., Zwicker, K. and Kerscher,S. Structure/ function relationships in mitochondrial complex I of the strictly aerobic yeast Yarrowia lipolytica. Biochem. Soc. Trans. (2005) 33:840-844.

  6. Galkin, A. and Brandt,U. Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica. Journal of Biological Chemistry (2005) 280:30129-3015.

  7. Duval R.A., Poupon, E., Brandt, U. and Hocquemiller, R. Remarkable substituent effect: ß-aminosquamocin, a potent dual inhibitor of mitochondrial complexes I and III. BBA-Bioenergetics (2005) 1709:191-194.

  8. Fandiño, A.S., Rais, I., Vollmer, M., Elgass, H., Schägger, H. and Karas, M. LC-nanospray-MS/MS analysis of hydrophobic proteins from membrane protein complexes isolated by blue-native electrophoresis. Journal of Mass Spectrometry (2005) 40:1223-1231.

  9. Wittig, I., Groner, B. Signal transducer and activator of transcription (STAT5) a crucial regulator of immune and cancer cells. Curr. Drug Targets Immune Endocr. Metabol. Disord. (2005) 449-463.

  10. Wittig, I., and Schägger, H. Advantages and limitations of clear native polyacrylamide gel electrophoresis. Proteomics (2005) 5:4338-4346.

  11. Dröse, S, Galkin, A. and Brandt,U. (2005) Proton pumping by complex I (NADH: ubiquinone oxidoreductase) from Yarrowia lipolytica reconstituted into proteoliposomes. BBA-Bioenergetics 1710:87-95.

  12. Abdrakhmanova,A., Dobrynin,K., Zwicker, K., Kerscher, S., Brandt, U. (2005) Functional sulfurtransferase is associated with mitochondrial complex I from Yarrowia lipolytica, but is not required for assembly of its iron-sulfur clusters.  FEBS Lett. 579:6781-6785.

Lehr- und Handbuchbeiträge, Monografien

  1.  Kerscher, S.,Zickermann, V., Zwicker,K. and Brandt, U. (2005) Insights into the mechanism of mitochondrial complex I from its distant relatives, the [NiFe] hydrogenases. in Biophysical and Structural Aspects of Bioenergetics, Wikström, M.K.F., Ed., pp 156-184, Royal Society of Chemistry, Cambridge, U.K.

Supplements / Abstracts

  1. Radermacher, M., Ruiz, T., Zickermann, V. and Brandt, U. (2005) Structure determination of complex I from Yarrowia lipolytica. Biophysical J. 88:329A Part 2 Suppl S

  2. Haendeler, J., Goy, C., Siebels, K., Droese, S. and Brandt, U. (2005) The reverse transcriptase activity of the enzyme telomerase reverse transcriptase reduces mitochondrial production of reactive oxygen species and binds to mitochondrial DNA. Circulation 112:U302 Suppl S